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and joint hypermobility) along with any minor criterion (soft doughy skin, easy bruising, fragile skin, molluscoid pseudotumors, subcutaneous spheroids, joint hypermobility complications, epicanthal folds, hernias, and positive family history), or by the presence of the major skin criterion and either generalized joint hypermobility and/or three or more minor criteria

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However, a GRAS designation does only apply for the conditions of the intended use scenario as a food additive and does not apply to inhalational intake through an e-cigarette 17