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Is nicotine a stimulant or a depressant? counselorssoapbox Intoxication: The Universal Drive for Mind Altering Substances: Siegel Ph.D., Ronald K.: 9781594770692 Books Puffing away sadness Harvard Health Nicotine reaches the brain extremely quickly typically within 7 to 10 seconds after inhalation. This rapid delivery creates a powerful and immediate dopamine response, reinforcing the urge to take another puff.
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