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doi: 10.1186/s12974-022-02602-y Summary Keywords exosomes, dendritic cell, cigarette smoke extract, silent information regulator 2 homolog 1, CD4+ T cells Citation Luo D, Liu J, Ya L, Ruan C, Ou S, Wei Y, Lin Q, Huang Z and Nong K (2026) Cigarette smoke exposure triggers dendritic cell-derived exosome-mediated Th17 and Treg polarization through an autophagy- and necroptosis-associated SIRT1-dependent mechanism in vitro