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Furthermore, no other model to date has demonstrated such a high level of bio-model complexity, as our study highlights the importance of co-culture systems and the inclusion of macrophages in smoke exposure models, which are essential for capturing the immune-inflammatory responses involved in COPD pathogenesis

40 to 50 percent of them smoke similar to the state average, and around 10 of them have quit

8 Limitations We evaluated 18 studies with relatively small cohorts of patients and relatively short follow-up periods, considering the time needed for UIAs to develop and change over time

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