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The interaction of genetic predisposition, harmful compounds released in cigarette smoke, metabolism of toxins, and intersection with concomitant risk factors influence the individual PAD expression ( Figure 1 The pathophysiology of PAD is complex and multifactorial and involves a variety of cells including endothelial cells, inflammatory cells, vascular smooth muscle cells, and platelets ( Multiple components of cigarette smoke are potentially harmful compounds

Approximately 1215 puffs from an Elf Bar equal the nicotine in one cigarette, but this varies depending on the users vaping style

Consult a healthcare provider for a personalised cessation plan

People who smoke cannabis approach the act of smoking differently