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As such, one plausible mechanistic account is that repeated stimulation of high densities of nAChRs by nicotine may contribute to neurotoxicity within discrete regions and/or increase the vulnerability of those regions to other volatile compounds in tobacco smoke [19] which ultimately manifest as gray matter decreases

This is a powerful and well-conducted study that adds to the emerging evidence of the added risk of cannabis regular use to the development of serious mental health disorders," said Beatriz Carlini, director of the Cannabis Research and Education program and an acting associate professor of psychiatry and behavioral sciences at the University of Washington's School of Medicine