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In conclusion, results suggested that patients who smoke may have a tendency toward a greater number of white matter lesions, and exhibit significantly more extensive normal-appearing white matter abnormalities, as detected by diffusion tensor imaging.

We wrote about those initial studies from 2011 in this article: Cigarettes, E-Cigarettes, and Substance Use in Adolescents The new data from 2019, published in the article Nicotine Gateway Effects on Adolescent Substance Use enhances and expands on the data from 2011

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