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Acknowledgments This research was supported by the National Institutes of Health Grant, GM57481 Abbreviations LMW low molecular weight n-MP 1-methylpyridinium dMP 1,1-dimethylpiperidium PNU-120596 1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)-urea TQS 3a,4,5,9b-tetrahydro-4-(1-naphthalenyl)-3H-cyclopentan[c]quinoline-8-sulfonamide GBC green coffee beans DRC dark roasted coffee Caf caffein Trg trigonelline Agm agmatine Spr spermine Tau taurine Lut lutidine: 2-AP, 1-(2-aminoethyl)pyrrolidine Footnotes Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication