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Covariates All models were adjusted for age, sex, education, socioeconomic status (household income and Townsend deprivation index [23]), body mass index (BMI), physical activity, diet, alcohol consumption, passive smoking, occupational exposure, the relatedness of individuals in the sample and first 20 principal components of ancestry

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For example, nicotine dependence levels increased at the beginning of the period but may decline by the end