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While nicotine acts as a stimulant in the central and peripheral nervous system of people and other mammals, it obstructs oxygen delivery by narrowing blood vessels throughout the body, including the ones in the umbilical cord

Acute limb ischemia, characterized by sudden drop in limb perfusion, is often caused by arterial emboli or in situ thrombi due to plaque progression and complication [22]

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Get tested for HIV because co-infection increases the likelihood of developing cirrhosis.