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Physicians must have a high index of suspicion and keep EVALI in their list of differential diagnoses when evaluating any unwell adolescent patient presenting to the office or emergency room

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Tobacco Health Risks The tobacco component introduces several health concerns: Nicotine addiction develops quickly, even with occasional spliff use Respiratory irritation tobacco smoke is more irritating than cannabis smoke alone Cardiovascular effects nicotine increases heart rate and blood pressure Cancer risk tobacco contains numerous carcinogenic compounds Reduced lung function combination smoking may compound respiratory impacts Medical Patient Considerations Medical cannabis patients should carefully weigh spliff use against their treatment goals