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J Gen Virol 89:15191524

"The person leading the program does a lot of research on nicotine dependence and has a lot of expertise that can bring in the most innovative and evidence based treatments to our patients." Yale Medicine research efforts, which often include free clinical trials that patients can join, include: The Yale Tobacco Treatment Clinic conducts clinical research into medications for smoking cessation

This makes their discovery the oldest known evidence of tobacco use in North America

Furthermore, tobacco smoking profoundly altered oral microbial composition, enriching Bifidobacterium , Lactobacillus , and the phylum Actinobacteria while depleting Proteobacteria, with notable taxa-level changes