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However, recent trends indicate an uptick in smoking rates among youth, highlighting the need for enhanced educational campaigns and stricter enforcement of age restrictions to prevent long-term addiction and health consequences

Varenicline The efficacy and safety of varenicline in helping hospitalized patients stop smoking, even in those with acute coronary syndrome, has been clearly demonstrated in 3 out of 4 clinical trials.1315,22 Varenicline should be used at the standard dose for a period of 12 weeks.12,33,34 In patients with a high degree of dependence or chronic respiratory diseases, it is highly advisable to use it at the dose and for the duration indicated by scientific societies such as the Spanish Society of Pulmonology and Thoracic Surgery and the European Respiratory Society.33,34 The major drawback for the use of varenicline in hospitalized patients is the need to administer it for 1 week before it becomes fully effective

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Finally, the sensitivity analysis results from application of human toxicity data for some of the compounds (alcohol, nicotine and THC 21,55,56,57 ) are shown in Supplementary Table S3 online and marked in Figures 13