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Pipe smokers also are at increased risk for lip cancers in areas where the pipestem rests

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There are relationships between cigarette smoking and heart diseases, and smoking increases the chances of having a heart attack, stroke and also cardiovascular complications

The main pathological changes are found in the small airways with epithelial remodeling including goblet cell metaplasia, basal cell hyperplasia, leading to thickening of small airway walls and obliteration [4]