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Clinically and mechanistically, PAH is distinguished by selective pathological remodeling of small distal pulmonary arteries, strong genetic susceptibility (e.g., bone morphogenetic protein type II receptor [BMPR2] gene mutations), and progressive pulmonary vascular dysfunction independent of left heart or parenchymal lung disease, making it the most extensively studied PH subtype in the context of molecular regulatory mechanisms (Ruopp and Cockrill 2022)

1 Answer 1 The difference in life expectancy between smokers and non-smokers appears to be at least 10 years on average, in a survey of American adults between 1997 and 2004

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