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2) On the basis of the studies included, the first manuscript was drafted and the recommendations were formulated according to the GRADE system (Table 1).4 All members of the expert group reviewed the document, adding comments and suggestions, and the second version of the document was prepared

Hyponatremia, respiratory depression, seizures Seizures A seizure is abnormal electrical activity of the neurons in the cerebral cortex that can manifest in numerous ways depending on the region of the brain affected