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The imaging results showed not only that inhalation of nicotine during cigarette smoking is solely responsible for occupancy of brain a4b2* nAChRs, but also that the imaging demonstrated significant a4b2* nAChR occupancy from smoking a denicotinized cigarette, state the authors

Cotinine was purchased from Alfa Aesar (Ward Hill, MA) and a stock solution (1 mg/mL) was prepared in methanol and stored at 20C

Smoking is a common risk factor for both COPD and osteoporosis