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By 2021, the market share for e-cigarettes, HTPs, and oral nicotine in HICs reached 3.9%, 5.1%, and 0.7%, respectively (Supplementary file Figure 1 A)

Key methodological advantages include: High extraction efficiency and recovery rates Excellent reproducibility and matrix robustness Reduced solvent consumption compared with conventional approaches Operational simplicity and rapid sample throughput Suitability for regulatory and routine monitoring laboratories Given the increasing regulatory stringency surrounding Maximum Residue Limits (MRLs) and international trade requirements, QuEChERS plays a critical role in ensuring compliance, consumer safety, and export market access particularly for fresh strawberries, where residue control is essential due to the crops delicate structure, rapid perishability, and high consumption rates