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They would also chew cured leaves to produce a feeling of euphoria and relaxationperhaps one of the first smokeless nicotine hits

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[86] Nicotine is a parasympathomimetic stimulant [89] that binds to and activates nicotinic acetylcholine receptors in the brain, [90] which subsequently causes the release of dopamine and other neurotransmitters, such as norepinephrine, acetylcholine, serotonin, gamma-aminobutyric acid, glutamate, endorphins, [91] and several neuropeptides, including proopiomelanocortin-derived -MSH and adrenocorticotropic hormone