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This nicotine dependence explains in part why e-cigarette users may be more likely to fail at smoking cessation, and is consistent with several recently published randomized controlled trials (RCTs) demonstrating no difference in cessation rates with e-cigarette use.2,3,4, 5 While these RCTs failed to demonstrate an effect on cessation rates, however, several reported an association between e-cigarette use and reduced conventional cigarette use