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As things stand, a smoker who cares to can at least learn from the cigarette ads the tar-and-nicotine content of the brand he is interested in buying, and if the commercial drive of the manufacturers can be channelled so that they are competing over brands with progressively reduced tar-and-nicotine content, the cause of public health may be advanced to the extent that the addictive force represented by the nicotine content of cigarettes is thereby reduced

Eissenberg, G

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It can be defined as an irreversible premature death of living body tissue that occurs when blood doesnt flow to any part of the body