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Nicotine in diseases Smoking inserts a high amount of xenobiotics, which in turn can alkylate DNA, activate specific (anti)inflammatory signals, and oxidative stress in active smokers and also second-hand smokers [167, 168]

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It was commonly used during periods of economic devastation (such as Reconstruction and Great Depression 1) to extend or replace tobacco supply

Electronic nicotine delivery systems (ENDs), also known as electronic cigarettes, e-cigarettes or vape pens, were introduced in the early 2000s as an alternative to tobacco products