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Although the proportion of tobacco use decreased with the improvement of policies and increased health awareness, the cumulative effect of early exposure might result in the trend of the disease burden, potentially reflecting a lag between the implementation of public health measures and their impact on disease burden

No star rating or ROS is assigned when the risk-outcome pair is found to have a 95% uncertainty interval estimated without between-study heterogeneity (i.e., using the fixed effects model results prior to the incorporation of gamma) that crosses the null

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