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A study by Shahab et al

Systems toxicology analyses detected biological effects of nicotine exposure, which included up-regulation of the xenobiotic-metabolizing enzymes CYP1A1 and FMO3 in the lung and metabolic effects, likely interlinked with a generalized stress response to nicotine present in the exposure aerosols [34]

The House version of the bill, authored by State Representative Ethan Cha, was laid over for possible inclusion in an omnibus bill during a House Commerce Committee hearing last month