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Cell types, including human fibroblasts, neutrophils, airway epithelial cells, human embryonic stem cells, and mouse neural stem cells, demonstrate morphological changes, even displaying cytotoxicity in stem cells and fibroblasts when exposed to undiluted e-liquid and flavor aldehydes, respectively (Wyatt et al., 2012), leading to an impaired ability to clear pathogens and debris from the airway

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