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In hepatocellular carcinoma (HCC) cells, ketoconazole downregulates the expression of COX2, thereby triggering PINK1-Parkin-mediated mitophagy to enhance apoptosis, downregulate BCL2, BCL-XL and MCL1 and upregulate BAX and BAK [25] (Fig

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And on this issue the congressmen are hearing from their local TV-station owners as well as from the N.A.B. Apart from the argument that regulatory action on cigarette advertising on the air would strengthen the agencies hand and thereby sap the power of Congress, the broadcasters maintained in their lobbying exercises that the broadcasting industry itself was perfectly capable of regulating its advertising of legal products such as cigarettes, and, in fact, was already monitoring and regulating the cigarette advertising that was offered it, through cigarette-advertising guidelines devised by the Television Code Authority, the administrative arm of the N.A.B.s Television Code Review Board

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