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[71] More than 90% of e-liquids contain nicotine

As retrospectively collected smoking status shows only moderate agreement with data collected prospectively [39], the accuracy of the gold standard may have been lower for these participants

However, the association with tobacco is plausible and justifies further investigation since psychotic illnesses are characterised by high levels of the neurotransmitter dopamine, and nicotine exposure increases the release of dopamine

Pleasure caused by nicotines interaction with the brains reward system motivates some people to use nicotine again and again, despite possible risks to their health and well-being