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In addition, in the case of infants, children, adolescents, and pregnant women, nicotine can impair brain development, potentially leading to cognitive and behavioural issues

Subluxation of the large joints may occur Other features include - poor response to local anaesthetic and reduced awareness of joint position (proprioception) Most patients with EDS have a normal life expectancy, however, the vascular type (Ehlers-Danlos syndrome IV) is associated with major complications that arise following spontaneous rupture of large arteries, as well as the colon and gravid uterus Clinical Images Please refer to notes on image rights at bottom of the page with regards to individual image ownership

These counterstrategies were used to work against a wide range of industry strategies, which are captured by five action-based strategies described in the PDM (Coalition Management, Information Management, Direct Access and Influence, Litigation, Reputation Management)

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