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Their objective was straightforward, and the design hardly ever played a role

The researchers' findings for men replicated those of an earlier study that found similar effects and provide further evidence of the value of the nicotine metabolite ratio biomarker to inform treatment for smokers trying to quit, Dermody said

McKee and Capewell cite a recent systematic review in Preventative Medicine that found serious methodological problems in many of the studies it reviewed and so many conflicts of interest that no firm conclusions can be drawn about the safety of e-cigarettes but that they can hardly be considered harmless

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