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Key comparison: Smoking: Higher levels of harmful chemicals (carbon monoxide, tar) Vaping: Fewer toxins, but still delivers nicotine and aerosol compounds If a mother cannot quit nicotine entirely, switching from smoking to vaping may reduce overall harm, but quitting both is the safest option

For DE comparisons between cell-type populations containing only non-smokers, we used a LR test with donor identity included as a latent variable