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This is why smokefree laws are a cornerstone of public health: they decrease exposure to toxins for everyone and help reduce tobacco use overall

Even if no pesticides were used to grow the tobacco in the cigarettes, its still tobacco, the authors note

Co-immunoprecipitation analysis showed that SESN2 directly interacts with p62, promoting the autophagic degradation of the p62-dependent target Keap1, and preventing oxidative damage (Bae et al., 2013)