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This is mainly due to the fact that, in the setting of subchronic CS exposure, menthol in menthol cigarettes can substantially decrease the absorption and/or increase the clearance of nicotine, thereby affecting the blood concentration of cotinine ( In summary, we demonstrated that relative to the subchronic exposure to Non-M-CS, the subchronic exposure to M-CS induced greater TRPM8-mediated activation of MAPKs and lung inflammation in mice

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