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This study shows that when smokers interested in reduction are provided with an e-cigarette with cigarette-like nicotine delivery, they are more likely to achieve significant decreases in tobacco-related toxicants, such as lower exhaled carbon monoxide levels. The researchers conducted a randomized controlled trial of 520 participants who smoked more than nine cigarettes a day, were not currently using an e-cigarette device, and were interested in reducing smoking but not quitting

Furthermore, those who are engaged in regular cigarette smoking showed significantly lower testosterone values

PMID 10160044

While they're alive, they're at significantly higher risk for cancer, heart disease, stroke, lung diseases, diabetes and a raft of other maladies