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While smokers often believe that light cigarettes are safer than others due to their low nicotine quantities, they are likely to inhale the same amount of chemicals from light cigarettes as regular cigarettes

However, a more detailed examination of the possible horizontal pleiotropy (i.e., a situation where candidate SNP instruments might be associated with the outcome through pathways independent of the exposure of interest) is required to disentangle the interplay between smoking behavior, alcohol intake, and PD risk