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Some studies suggested that nicotine may regulate platelet activation by decreasing aggregation, thereby decreasing thrombosis [28], while other studies showed that nicotine has no effect on platelet activity [29]

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ClinicalTrials.gov now also reflects a gradual shift away from nicotine cessation and toward product switching, nicotine transfer, combination therapies, and harm-reduction studies involving e-cigarettes and nicotine pouches.[11][12][13] That matters because frustrated cessation researchers are quietly morphing quitting into transfer