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Carcinogens like polycyclic aromatic hydrocarbons (PAHs) and nitrosamines, produced during tobacco combustion, directly cause mutations in the DNA of cells, triggering uncontrolled cell growth and tumor formation

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Magda Walicka, Department of Human Epigenetics, Mossakowski Medical Research Institute, Polish Academy of Sciences, 5 Pawiskiego str, 02-106 Warsaw, Poland, Department of Internal Diseases, Endocrinology and Diabetology, The National Institute of Medicine of the Ministry of Interior and Administration, 137 Wooska str., 02-507 Warsaw, Poland