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This enormous improvement was largely the result of improved nutrition, housing, hygiene and food handling

Reducing Cholesterol Synthesis or Promoting Cholesterol Efflux in Airway Epithelial Cells Protects Against Cigarette Smoke Extract-Induced Inflammation To further investigate whether changes in intracellular cholesterol levels contribute to the development of cigarette smoke-induced airway inflammation, we silenced the expression of cholesterol biosynthesis-related molecules SREBP2 and HMGCR in HBE cells using siRNA (Figure 3A and B) and inhibited cholesterol biosynthesis in HBE cells using the inhibitor lovastatin (Figure 3F and G)

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