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For instance, in acute inflammatory situations, such as sepsis or viral infection, there is a rise in the intracellular redox state, and all cell compartments are vulnerable to oxidative stress (characterized by increased levels of ROS, and low removal by the antioxidant system) [10,39]

Cortisol responses may vary depending on fasting duration, circadian rhythm, stress levels, sleep quality, and population characteristics, yet these variables are often underreported [45, 46]