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In patients with CS-induced COPD, the pro-inflammatory Wnt5a and cytokines including interleukin (IL)-8, IL-1, IL-6 and tumor necrosis factor (TNF)- in serum EVs were significantly elevated [52]

and (ii) any amounts payable by the Buyer to the Company in consideration for any taxable supply made by the Company to the Buyer under this agreement and any GST payable on the supply in accordance with clause 23.2(b)

[22] As of 2017, they were not approved by the US Centers for Disease Control and Prevention (CDC) as a smoking cessation product, [8] and in 2020, they became regulated as a tobacco product, despite not containing tobacco

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