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Interactive effects of alcohol and nicotine on dopamine release in the Download Scientific Diagram When nicotine from a cigarette reaches your brain, it releases dopamine, the chemical that makes you feel good for a short time. This is what starts the addiction., Nicotine also changes other brain When nicotine from a cigarette reaches your brain, it releases dopamine, the chemical that makes you feel good for a short time. This is what starts the addiction. Nicotine also changes other For smokers only: understanding and silencing the wanting within

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