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As the body does with alcohol, caffeine, or other drugs, it can interpret high doses as toxic, resulting in dizziness, nausea, and vomiting. On top of increasing the activity of the central nervous system, nicotine makes users more prone to cardiovascular issues by narrowing and stiffening blood vessels

and they could fine or detain you." Two governments, saying the same thing, on the record

Even a tiny crumb of cross-contaminated bread can trigger a massive immune response

Such trials typically enrolled smokers especially concerned about gaining weight and randomised them to standard support for smoking cessation or standard support plus an intervention to prevent weight gain