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Abstract Background Genetic variation increases the risk of lung cancer, but the extent to which smoking amplifies this effect remains unknown

We also excluded men with incomplete information on cigarette or cigar use or demographic characteristics (i.e., race/ethnicity, education and marital status), so the final sample for our analyses was 43,202 men (age 4059 years, n = 27,229 and age 5079 years, n = 15,973) with 588,761 person-years and 14,657 deaths

Smoking cigarettes seems to indicate his resignation to being a 'bad' man, a way to punish himself

We found that, due to small numbers of studies, inconsistency in the data, small effect sizes or a combination of these reasons, seven outcomes for which some previous research had found an association with smoking did notunder our meta-analytic framework and conservative approach to interpreting the datahave evidence of an association