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In addition, depending on the level of sophistication of the production, illegal manufacturers need machinery to produce and to package the cigarettes

Analysis of tobacco industry marketing research and market segmentation studies has shown that historically the tobacco industry has used psychosocial and other personality traits to develop targeted promotional strategies that encourage uptake of tobacco use [10, 50, 51]

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Causes most commonly include ileal disease or resection, fistulas, small bowel bacterial overgrowth, reduced intake, increased physiologic requirements, protein-losing enteropathy, and hepatic dysfunction