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Key clinical features include: Progressive exertional dyspnea the cardinal symptom, initially on exertion and advancing to rest in severe disease Dry, nonproductive cough persistent and often refractory to standard antitussives Bibasilar inspiratory crackles (Velcro crackles) present in ~80% of IPF patients on auscultation Digital clubbing present in up to 50% of IPF cases

4.Worsens Other Risk Factors If you have diabetes or high cholesterol, smoking makes those conditions worseand both diabetes and heart disease are top contributors to CKD