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Background Under normal conditions, cough is an important protective mechanism that clears foreign material from the airways and aids in immune defence (Fontana et al., 1999)

Bullae may rupture leading to pneumothorax Risk factor for COPD Cigarette smoking Occupational exposure (Coal dust, Silica) Indoor air pollution Recurrent infection Premature birth Alpha 1 antitrypsin deficiency IgA deficiency Etiology for Acute exacerbation of COPD Viral respiratory infections arethemost common cause of AECOPD, among them Rhinovirus isthe most common cause of acute exacerbation ofCOPD

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