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I found out about it while arguing with someone who claims that American Spirit cigarettes are better for you than other brands (The FDA has warned American Spirit to stop with its natural and additive-free advertising

"Mortality in relation to smoking: 50 years' observation on male British doctors"

Both animal and human studies have highlighted the occurrence of sperm DNA-strand breaks (fragmentation), genome instability, genetic mutations, and the presence of aneuploids in the germline of animals and men exposed to tobacco smoke

The overall margin of error is +/-2.8% at a 95% level of confidence, with higher margins of error for subgroups