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With this study, we have found that people who smoke a pack a day develop an average of 150 extra mutations in their lungs every year, which explains why smokers have such a higher risk of developing lung cancer. Additionally, other organs were also affected and the study showed that a pack a day led to an estimated average 97 mutations in each cell in the larynx, 39 mutations for the pharynx, 23 mutations for the mouth, 18 mutations for the bladder, and 6 mutations in every cell of the liver each year

Our data complement and extend those findings by demonstrating that the risk of MLHD is significantly reduced after 5 years or more of smoking cessation among patients with less than 10 pack-years of smoking (Fig 10)

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