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Maximum safe exposure levels for workers over an 8-hour period range from 25 to 50 ppm

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In the United States, the 5-year survival rate of localized cancers that are treated is more than 80%, whereas of those spread to distant organs is 30%

Absent the unlikely situation that the additives would eliminate tobacco smoke's genotoxicity and mutagenicity, the failure to find increased toxicity associated with the additives does not support the conclusion that in vitro mutagenicity and cytotoxicity of the cigarette smoke were not increased by the addition of the ingredients [17]