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The study was published recently in Chemical Research in Toxicology

2.3 Smoking, SNS and RAAS The RAAS and the SNS are major physiological systems which play an important role in normal physiology as well as in pathologic conditions

But that could never be proven until our study, since there was no way to accurately quantify mutations in normal cells, said Jan Vijg, Ph.D., a study co-senior author and professor and chair of genetics, professor of ophthalmology and visual sciences, and the Lola and Saul Kramer Chair in Molecular Genetics at Einstein (also at the Center for Single-Cell Omics, Jiaotong University School of Medicine in Shanghai, China)

I converted this into total use assuming that 5 percent of high school students use cigarettes (cited here) and 11.7 percent use e-cigarettes (cited in the first paragraph of the MMWR report)