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Statement on the toxicological evaluation of novel heatnotburn tobacco products

Mice were anesthetized by intraperitoneal injection with a 0.2 mL/10 g tribromoethanol solution, fixed on a brain stereotactic instrument equipped with a circulating water insulation system, and erythromycin ointment was applied to the eyes of mice to avoid injury from surgical glare

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Avoid chewing too hard or too often to prevent breaking up the tobacco too much or irritating your mouth